Table 5.
Serum phosphate levels and cause-specific mortality in men from RS-I and RS-II, adjusted for age, BMI and smoking, follow-up until year 2012
| Individual cohorts | Studies combined | |||||
|---|---|---|---|---|---|---|
| Cohort | n | HR* (95% CI) | p | HR† (95% CI) | p | |
| CVD | RS-I | 266 | 1.80 (1.35–2.39) | < 0.001 | 1.66 (1.29–2.14) | < 0.001 |
| RS-II | 77 | 1.25 (0.73–2.15) | 0.412 | |||
| Cancer | RS-I | 243 | 1.41 (1.04–1.90) | 0.025 | 1.23 (0.95–1.58) | 0.112 |
| RS-II | 98 | 0.88 (0.55–1.40) | 0.586 | |||
| External | RS-I | 18 | 1.58 (0.50–5.02) | 0.439 | 0.94 (0.36–2.46) | 0.902 |
| RS-II | 9 | 0.29 (0.05–1.62) | 0.159 | |||
| Infectious | RS-I | 56 | 1.02 (0.53–1.98) | 0.943 | 0.97 (0.53–1.80) | 0.929 |
| RS-II | 9 | 0.71 (0.13–3.84) | 0.691 | |||
| Dementia | RS-I | 52 | 1.83 (0.93–3.60) | 0.081 | 1.70 (0.92–3.15) | 0.092 |
| RS-II | 13 | 1.18 (0.26–5.37) | 0.826 | |||
| Lung | RS-I | 42 | 2.07 (0.97–4.42) | 0.058 | 1.94 (1.02–3.72) | 0.044 |
| RS-II | 15 | 1.64 (0.47–5.72) | 0.441 | |||
| Other | RS-I | 133 | 1.58 (1.04–2.41) | 0.032 | 1.67 (1.16–2.40) | 0.006 |
| RS-II | 40 | 1.98 (0.96–4.11) | 0.066 | |||
Statistically significant p-values (<0.05) are highlighted in bold font
*Hazard ratios from Weibull models, expressed per 1 mg/dL (0.32 mmol/L) increase in phosphate levels
†Studies combined from meta-analyses using fixed-effect models