Table 2.
Summary linear estimates of associations between sedentary behaviour (hours/day) with major chronic disease outcomes from random-effects meta-analysis
| Outcome (cases/n baseline) | Exposure (number of contributing studies for non-PA adjusted/PA adjusted estimates) | Without PA adjustment | With PA adjustment | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Summary RR (95%CI) | p value RR = 1 | I2 (%) | p value non-linearity | Summary RR (95%CI) | p value RR = 1 | I2 (%) | p value non-linearity | ||
| All-cause mortality (110,395/1,138,042) | Total sedentary behaviour (12/13) | 1.03 (1.02, 1.04) | < 0.001 | 49.7 | < 0.001 | 1.02 (1.01, 1.03) | < 0.001 | 65.6 | < 0.001 |
| TV viewing (7/7) | 1.07 (1.04, 1.09) | < 0.001 | 70.9 | < 0.001 | 1.05 (1.04, 1.05) | < 0.001 | 0 | < 0.001 | |
| CVD mortality (24,042/667,524) | Total sedentary behaviour (6/5) | 1.03 (1.02, 1.03) | < 0.001 | 0 | 0.001 | 1.02 (1.01, 1.03) | 0.004 | 22.7 | 0.010 |
| TV viewing (5/6) | 1.05 (1.02, 1.09) | 0.005 | 90.1 | 0.203 | 1.04 (1.01, 1.08) | 0.028 | 88.8 | < 0.001 | |
| Cancer mortality (35,241/684,673) | Total sedentary behaviour (6/5) | 1.01 (1.00–1.02) | 0.212 | 84.1 | 0.168 | 1.01 (1.00, 1.02) | 0.268 | 77.3 | 0.326 |
| TV viewing (4/4) | 1.03 (1.02, 1.04) | < 0.001 | 0 | 0.642 | 1.02 (1.01, 1.03) | < 0.001 | 0 | 0.648 | |
| Type 2 diabetes (17,552/400,292) | Total sedentary behaviour (4) | [Insufficient number of studies] | 1.01 (1.00, 1.01) | < 0.001 | 0 | 0.529 | |||
| TV viewing (5/6) | 1.12 (1.08, 1.16) | < 0.001 | 65.9 | 0.767 | 1.09 (1.07, 1.12) | < 0.001 | 31.7 | 0.066 | |