Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Apr 26;75(19):3609–3624. doi: 10.1007/s00018-018-2813-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

Fig. 1 — OPN4 genetic variants selected for in vitro screening. Location of 96 naturally occurring non-synonymous amino acid substitutions (thick black outline) in the human OPN4 protein, of which 16 (red) were screened using immunocytochemistry and calcium imaging of melanopsin-driven light responses. Location of variants not screened in vitro (yellow) and the K340A control mutation (black) is also shown. Secondary structure based on homology with bovine rhodopsin [47]