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. 2017 Dec 1;25(4):1204–1236. doi: 10.1007/s12350-017-1131-5

Table 2.

Tracers for perfusion imaging

Tracer Chemical structure* Type of tracer Production Half -life Positron range (mm) Scan duration (rest and stress) Intravenously administered activity (MBq) Effective dose (mSv/MBq) Approval year
FDA Europe Japan
SPECT
 201Thalium 201Tl+ Metal cation Cyclotron 73 h 4-h 74–148 0.23 1977 1980** 1991
 99mTc-sestamibi graphic file with name 12350_2017_1131_Figa_HTML.gif Metal complex Generator 6 h 4-h or 2-days 740–1480 0.0085 1990 1987** 1993
 99mTc-tetrofosmin graphic file with name 12350_2017_1131_Figb_HTML.gif Metal complex Generator 6 h 4-h or 2 days 740–1480 0.0067 1996 1993** 1996
 99mTc-teboroxime Generator 6 h 1990
PET
 82Rubidium 82Rb+ Metal cation Generator 76 s 8.6 30-min 370–740 0.0048 1989
 13N-ammonia 13NH3 Inorganic compound Cyclotron 9.96 min 2.53 1.5-h 370–740 0.0022 2007 2012
 15O-water H152O Inorganic compound Cyclotron 2.04 min 4.14 30-min 370–740 0.0011
 18F-flurpiridaz graphic file with name 12350_2017_1131_Figc_HTML.gif Organic compound Cyclotron 109.8 min 1.03 1.5-h or 2 days 222–370 0.019

*The mass number of 99mTc was omitted

**EURD List Juli 2017: http://www.ema.europa.eu/docs/en_GB/document_library/Other/2012/10/WC500133159.xls