Table 2.
Tracers for perfusion imaging
Tracer | Chemical structure* | Type of tracer | Production | Half -life | Positron range (mm) | Scan duration (rest and stress) | Intravenously administered activity (MBq) | Effective dose (mSv/MBq) | Approval year | ||
---|---|---|---|---|---|---|---|---|---|---|---|
FDA | Europe | Japan | |||||||||
SPECT | |||||||||||
201Thalium | 201Tl+ | Metal cation | Cyclotron | 73 h | – | 4-h | 74–148 | 0.23 | 1977 | 1980** | 1991 |
99mTc-sestamibi |
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Metal complex | Generator | 6 h | – | 4-h or 2-days | 740–1480 | 0.0085 | 1990 | 1987** | 1993 |
99mTc-tetrofosmin |
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Metal complex | Generator | 6 h | – | 4-h or 2 days | 740–1480 | 0.0067 | 1996 | 1993** | 1996 |
99mTc-teboroxime | Generator | 6 h | – | 1990 | – | – | |||||
PET | |||||||||||
82Rubidium | 82Rb+ | Metal cation | Generator | 76 s | 8.6 | 30-min | 370–740 | 0.0048 | 1989 | – | – |
13N-ammonia | 13NH3 | Inorganic compound | Cyclotron | 9.96 min | 2.53 | 1.5-h | 370–740 | 0.0022 | 2007 | – | 2012 |
15O-water | H152O | Inorganic compound | Cyclotron | 2.04 min | 4.14 | 30-min | 370–740 | 0.0011 | – | – | – |
18F-flurpiridaz |
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Organic compound | Cyclotron | 109.8 min | 1.03 | 1.5-h or 2 days | 222–370 | 0.019 | – | – | – |
*The mass number of 99mTc was omitted
**EURD List Juli 2017: http://www.ema.europa.eu/docs/en_GB/document_library/Other/2012/10/WC500133159.xls