Fig. 5.

Levels of fusion-mediating proteins (i.e., OPA-1 and Mfn2) and fission-mediating proteins (i.e., Fis-1 and Drp-1) in NL dogs, dogs with HF (HF-CON), and dogs with HF treated with ELAM (HF + ELAM). Drp-1 = dynamin-related protein-1; du = densitometric units; Fis-1 = fission-1; HF = heart failure; HF-CON = dogs with HF who served as controls; HF + ELAM = dogs with HF who received treatment with ELAM; Mfn2 = mitofusin-2; NL = normal animals; OPA-1 = optic atrophyy-1