FIGURE 4.

Quantitative polymerase chain reaction data for spleen cells from mice whose TC1 tumor regressed and did not recur after treatment with the 3 mAb combination intratumorally plus cisplatin intraperitoneally. Naive mice received the 3 mAb combination subcutaneous and cisplatin intraperitoneally; data are included from tumor-bearing mice which received control mAbs and no cisplatin. The data indicate that a shift from Th2 to Th1 immune status accompanies the cure of TC1 tumors. IFN indicates interferon; IL, interleukin; mAb, monoclonal antibody.