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. 2018 Jun 15;41(8):369–378. doi: 10.1097/CJI.0000000000000231

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Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/

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A, Flow cytometry for TIL from mice whose TC1 tumors either responded (partial regression) or did not respond (progressive growth) after treatment with the 3 mAb combination plus cisplatin. B, Enlarged spleen and increased CD11b⁺Gr1⁺ and IDO⁺ cells in spleen from a mouse with recurrent tumor compared with a cured mouse. C, Increased expression of arginase and reversed M1/M2 response in the spleen of a mouse with recurrent tumor. mAb indicates monoclonal antibody; TIL, tumor-infiltrating lymphoid cells.