Table 4.
P-values for association of fasting glucose level with all gene regions on 22 chromosomes in the GO-ESP data
| Gene | Chr | # genotyped SNPs | p-value based on
|
|||
|---|---|---|---|---|---|---|
| ABT | FBT | KT | MONSTER | |||
| EDF1 | 9 | 7 | 2.43 × 10−11 | 3.22 × 10−7 | 9.11 × 10−11 | 1.18 × 10−4 |
| RNF214 | 11 | 19 | 3.93 × 10−11 | 7.51 × 10−8 | 1.21 × 10−12 | 7.73 × 10−5 |
| CENPL | 1 | 4 | 7.83 × 10−11 | 1.77 × 10−8 | 8.21 × 10−11 | 1.65 × 10−5 |
| OR2F2 | 7 | 8 | 1.15 × 10−9 | 4.33 × 10−1 | 3.54 × 10−5 | 1.64 × 10−6 |
| SMAD5 | 5 | 9 | 2.99 × 10−9 | 1.55 × 10−3 | 7.66 × 10−6 | 9.26 × 10−7 |
| UBASH3A | 21 | 41 | 4.44 × 10−9 | 9.46 × 10−2 | 1.16 × 10−5 | 3.16 × 10−5 |
| IGLL3P | 22 | 13 | 4.92 × 10−9 | 8.48 × 10−3 | 7.02 × 10−9 | 5.56 × 10−5 |
| TNFSF13B | 13 | 8 | 9.30 × 10−9 | 8.27 × 10−5 | 3.03 × 10−7 | 3.88 × 10−5 |
| MIF4GD | 17 | 8 | 1.55 × 10−8 | 2.76 × 10−4 | 3.14 × 10−5 | 1.55 × 10−5 |
| MILR1 | 17 | 6 | 2.21 × 10−8 | 9.67 × 10−5 | 6.95 × 10−10 | 8.66 × 10−6 |
Note: The quantitative trait—average fasting glucose level (log-transformed) was adjusted for age and sex. For FBT, KT, and MONSTER, Madsen-Browning weights were used. MIM numbers of genes: EDF1[605107], CENPL[611503], SMAD5[603110], UBASH3A[605736], TNFSF13B[ 603969], MIF4GD[612072].