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Stability of differently capped mRNAs in HEK293 cells.
| Remaining mRNAs in % |
|||
|---|---|---|---|
| cap analog on 5ʹ end | 4h | 24h | 48h |
| m7GpppG | 100 | 67.4 ± 1.4 | 36.8 ± 2.6 |
| ApppG | 100 | 48.5 ± 0.5 | 37.0 ± 1.5 |
| m27,3ʹ-OGpppG | 100 | 71.7 ± 1.0 | 54.1 ± 1.5 |
| bn2m27,3ʹOGpppG (9) | 100 | 95.0 ± 3.1 | 76.7 ± 1.0 |
| (p-OCH3bn)2m27,3ʹOGpppG(10) | 100 | 73.3 ± 2.0 | 55.1 ± 1.6 |
| bn2m27,2ʹOGpppG (11) | 100 | 85.7 ± 3.0 | 76.5 ± 4.6 |
