Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 21;17(13):1667–1681. doi: 10.1080/15384101.2018.1491235

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Informa UK Limited, trading as Taylor & Francis Group

PMC Copyright notice

Figure 1. — Pre-senescent fibroblasts are under replication stress. (a) Scheme of induced cellular senescence by serial passaging. Pre-senescent cells (two passages before RS) were analyzed. B-C DNA combing from asynchronous cells successively labeled with IdU (red) and with CldU (green) of proliferative (b) and pre-senescent (c) IMR90 fibroblasts. DNA fibers are shown in blue. (d) Inter-Origin Distance and fork velocity are significantly decreased in pre-senescent IMR90 fibroblasts. (e-g) Mapping short nascent strands (SNSs) by DNA sequencing detected fewer origins peaks (e), a decreased size of initiation zones (f) and increased number of regions without detectable origins (g).