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. 2018 Aug 21;17(13):1667–1681. doi: 10.1080/15384101.2018.1491235

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Figure 3. — RT changes upon entry to cellular senescence. (a) Overlap analysis of significant RT variable regions identifying a unique region that changes upon entry to cellular senescence in all primary cells analyzed (OIS_IMR90 shown in red, PreS_IMR90 shown in yellow, PreS_BJ shown in green, PreS_Fibro74yrs shown in blue). (b) RT profiles of proliferative and pre-senescent cells from fetal fibroblasts (IMR90), from neonatal cells (BJ) and from fibroblasts of a 74 year-old donor, centered at the unique region that switches from early to late replication in pre-senescent cells. This locus is on chromosome 7 and contains the CREB5 gene. (c) Expression levels of CREB5 in normal (IMR90), senescent (OIS_ IMR90) and a senescence bypass model (IMR90_OIS_bypass). Transcription data are from [46].