Table 1.
LincRNAs directly regulated by p53 with functions potentially relevant to p53-mediated tumor suppression.
| Name | Reported function | Ref. |
|---|---|---|
| PANDA | Interacts with NF-YA to inhibit the expression of pro-apoptotic genes upon DNA damage and promote cell survival. | [9] |
| NEAT1 | Suppresses cellular transformation in oncogene-expressing fibroblasts and in the pancreas by enforcing the expression of differentiation genes. It can enhance cell proliferation, cell survival, cell invasion and EMT in some cancer cell lines. Finally, it can promote ATR signaling upon replication stress, preventing the accumulation of DNA damage. | [24,25,48,50–55] |
| PINCR | Interacts with Matrin 3, inducing cell cycle arrest and cell survival upon DNA damage in human colorectal cancer cells. | [14] |
| TUG1 | Interacts with PRC2 and represses HOXB7, decreasing cell proliferation in non-small cell lung cancer. | [15,16] |
| PVT1 | The PVT1 locus contains the lincRNA PVT1 and different microRNAs, including miR-1204, which was shown to have antiproliferative effects and to trigger apoptosis through the increase of p53 levels. PVT1 was also shown to promote cell survival. | [11,12] |
| lincRNA-p21 | Interacts with hnRNP-K to act as a global mediator of p53-dependent repression and is required for cell cycle arrest and apoptosis induction in response to DNA damage. | [7,8] |
| DINO | Enhances p53 stabilization upon DNA damage. | [19] |
| PURPL | Destabilizes p53 under basal conditions. | [20] |
| PR-lncRNA-1,10 | Act to facilitate p53 binding to target genes, promoting cell cycle arrest and inducing cell death upon DNA damage. | [13] |
| PINT | Interacts with PRC2 to inhibit proliferation in human cells. In mouse cells, promotes proliferation and survival. | [10] |
| Loc285194 | Inhibits miR-211 to limit proliferation of colorectal and breast cancer cell lines in vitro. It also dampens subcutaneous tumor growth of colorectal cancer cells. | [21] |
| LED | Binds and activates strong enhancers, supporting the p53 transcriptional response and inducing cell cycle arrest upon p53 activation. | [17] |
| TRINGS | Interacts with STRAP and inhibits necrosis upon glucose starvation. | [18] |