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. 2018 Sep 11;13(9):e0202792. doi: 10.1371/journal.pone.0202792

Table 3. Variant density for individual genes from subsystems with high variance score (excluding unknown genes and categories).

variants /bp SEED Annotation
  Product Subsystem(s)
4.7 Nitrogen regulatory protein P-II Ammonia assimilation
4.0 Transaldolase (EC 2.2.1.2) Pentose phosphate pathway
3.9 Endonuclease V (EC 3.1.21.7) DNA repair, bacterial
3.7 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance
3.7 Octaprenyl-diphosphate synthase / Dimethylallyltransferase / Geranyltranstransferase / Geranylgeranyl pyrophosphate synthetase Carotenoids
Isoprenoid Biosynthesis
Polyprenyl Diphosphate Biosynthesis
3.6 Glycosyltransferase CBSS-258594.1.peg.3339
3.4 Maltose/maltodextrin ABC transporter, substrate binding periplasmic protein MalE Bacterial Chemotaxis
Maltose and Maltodextrin Utilization
3.4 Cytochrome d ubiquinol oxidase subunit II (EC 1.10.3.-) Bacterial RNA-metabolizing Zn-dependent hydrolases
Conserved gene cluster associated with Met-tRNA formyltransferase
3.1 3-oxoacyl-[acyl-carrier-protein] synthase, KASIII (EC 2.3.1.41) Fatty Acid Biosynthesis FASII
3.0 Transketolase (EC 2.2.1.1) Calvin-Benson cycle
Pentose phosphate pathway
3.0 Glutamate racemase (EC 5.1.1.3) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis
2.8 cAMP-binding proteins—catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases CBSS-258594.1.peg.3339
2.8 Glycosyltransferase CBSS-258594.1.peg.3339
2.8 Glycosyl transferase, group 1 CBSS-258594.1.peg.3339
2.7 Phosphate transport system permease protein PstA High affinity phosphate transporter and control of PHO regulon
2.7 cAMP-binding proteins—catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases CBSS-258594.1.peg.3339
2.6 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS High affinity phosphate transporter and control of PHO regulon
2.5 Gamma-glutamyltranspeptidase (EC 2.3.2.2) Glutathione: Biosynthesis and gamma-glutamyl cycle
2.4 N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9) Sialic Acid Metabolism
2.4 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) Rhamnose containing glycans
2.4 Octaprenyl-diphosphate synthase / Dimethylallyltransferase / Geranyltranstransferase / Geranylgeranyl pyrophosphate synthetase Carotenoids
Isoprenoid Biosynthesis
Polyprenyl Diphosphate Biosynthesis
2.3 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) Rhamnose containing glycans
2.3 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism
2.2 3-oxoacyl-[acyl-carrier-protein] synthase, KASII (EC 2.3.1.41) Fatty Acid Biosynthesis FASII
2.2 Maltodextrin glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization
2.2 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis
2.2 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon
2.2 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial
2.2 Cryptochrome DNA repair, bacterial photolyase
2.2 Gamma-glutamyltranspeptidase (EC 2.3.2.2) Glutathione: Biosynthesis and gamma-glutamyl cycle
2.2 Chemotaxis protein CheC—inhibitor of MCP methylation Bacterial Chemotaxis
2.1 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100) Fatty Acid Biosynthesis FASII
2.0 O-antigen export system, permease protein Rhamnose containing glycans
2.0 Putative sucrose phosphorylase (EC 2.4.1.7) Maltose and Maltodextrin Utilization
2.0 DNA-cytosine methyltransferase (EC 2.1.1.37) DNA repair, bacterial
2.0 4'-phosphopantetheinyl transferase (EC 2.7.8.-) Fatty Acid Biosynthesis FASII