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. 2018 Aug 27;4(9):e387. doi: 10.1097/TXD.0000000000000827

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Copyright © 2018 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Study design. Sensitization experiments we conducted by transfusing 500 μL of heparinized blood from BN rats in Lewis recipients on day 0 (groups T2-T10). Two types of intervention were then defined based on whether syngeneic or allogeneic MSC were delivered to Lewis rats before (“prevention” groups) or after (“treatment” groups) sensitization. Lewis Rats in Prevention groups received tail vein injections of MSC from Lewis or BN at 2 M (T3, T5), 1 M (T7) or 0.5 M (T9) per injection on days −2, 3, 6, 9, 12 (5 total doses). Rats in Treatment groups (T4, T6, T8, T10) received the same treatment on days 14, 17, 20, 23, 26. Group T1 was composed of untreated Lewis rats (no transfusion, no MSC), while group T2 was composed of only sensitized Lewis rats. Animals were randomized into each treatment groups and remained in protocol for 4 weeks after transfusion. There were 10 groups total (n = 6 per group).