Table 3. Details of positive margin location and clinical outcome after radical skull base surgery.

Pathological margin status	Histopathology	Primary location	Induction chemotherapy	Approach to the skull base	Location of positive margin	Postoperative treatment	Local recurrence	Outcome
Micro margin positive	RMS	Nasal cavity	Positive	Frontal craniotomy	Lateral nasal wall	CRT	Negative	DOD
Micro margin positive	ES	Paranasal sinus	Positive	Frontal craniotomy	Oribital apex	CRT	Negative	NED
Micro margin positive	OS	Oral cavity	Negative	temporal craniotomy	Mandibular bone	CRT/surgery	Negative	NED
Micro margin positive	UUS	Orbit	Negative	frontotemporal craniotomy	Dura (near sinus)	RT	Negative	NED
Micro margin positive	RMS	Paranasal sinus	Positive	Orbital exenteration, maxillectomy	Lateral nasal wall	CRT	Negative	NED
Micro margin positive	RMS	Parapharyngeal space	Positive	Zygomatic approach	Masseter	CRT	Negative	NED
Wide margin positive	RMS	Parapharyngeal space	Positive	Frontal craniotomy	Skull bone/Orbital apex	chemotherapy	Orbita	DOD
Wide margin positive	UUS	Temporal fossa	Positive	temporal craniotomy	Orbital periosteum/Dura	CRT	Oribta	AWD
Wide margin positive	RMS	Nasopharynx	Positive	Mandibular swing approach	Clivus/Nasopharynx	CRT	Nasopharynx	DOD
Wide margin positive	UUS	Temporal fossa	Negative	Coronal incision approach	Piece by piece resection	CRT	Negative	NED

Abbreviations: DOD, die of disease; ES, Ewing's sarcoma; NED, no evidence of disease; OS, osteosarcoma; RMC, rhabdomyosarcoma; UUS, undifferentiated/unclassified sarcoma.