TABLE 1.
Various roles of MaRs
| Bioactive resolution | Action | Model system/cell type | Reference |
|---|---|---|---|
| MaR-1 (7R,14S-dihydroxy-docosa-4Z,8E,10E,12Z,16Z,19Z-hexaenoic acid) | ↓ PMN infiltration, ↑ phagocyte clearance | Murine peritonitis/lung | 110 |
| Antinociceptive | Mouse/pain | 111 | |
| ↓ PMN infiltration and cytokine expression as well as NF-κB activation | Mouse/colitis | 112 | |
| ↑ Tissue regeneration in Planaria | Planaria/regeneration | 90 | |
| Phenotype switch | Human macrophages | 75 | |
| ↑ Apoptotic PMNs | Human macrophages | 90 | |
| ↑ Phagocytosis and efferocytosis | Human macrophages | 73, 113 | |
| ↓ Cytokine release with organic dust | Human bronchial epithelial cells | 114 | |
| Identified in synovial fluid extracts | Human/rheumatoid arthritis | 115 | |
| MaR-2 (13R,14S-dihydroxy-4Z,7Z,9E,11Z,16Z,19Z-DHA) | ↓ PMN infiltration | Human macrophages | 76 |
| ↑ Phagocytosis and efferocytosis | Human macrophages | 76, 116 |