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. Author manuscript; available in PMC: 2019 Sep 18.
Published in final edited form as: Biochem Biophys Res Commun. 2018 Aug 9;503(4):2619–2624. doi: 10.1016/j.bbrc.2018.08.013

Figure 1. RILP is a direct substrate of caspase-1.

Figure 1.

(A) SeV-induced RILP cleavage can be blocked by pharmacological inhibition of caspase-1. (B) Silencing of caspase-1 by shRNA blocks the cleavage of RILP. (C) Titration of caspase-1 overexpression (0, 1.25, or 2.5 µg) shows increased RILP cleavage corresponding with an increase in caspase-1 expression. (D) Purified RILP protein is cleaved at D75 by caspase-1 but not caspase-3. (E) Sendai virus causes cRILP to re-localize to the cellular periphery. Mutation of the caspase cleavage site D75 to alanine blocks this.