Table 3.
Risk of outcomes by CHA2DS2-VASc score and chronic kidney disease stage.*
| Outcome Evaluated Variable |
Hazard Ratio |
95% CI | P-value | |
|---|---|---|---|---|
| Lower | Upper | |||
| Death | ||||
| CHA2DS2-VASc Score | 1.35 | 1.27 | 1.43 | <.0001 |
| Chronic Kidney Disease Stage | 1.58 | 1.33 | 1.89 | <.0001 |
| CHA2DS2-VASc 3–6 | 6.55 | 2.42 | 17.68 | 0.0002 |
| CHA2DS2-VASc 7–9 | 15.08 | 5.48 | 41.46 | <.0001 |
| Chronic Kidney Disease 2 | 0.69 | 0.40 | 1.20 | 0.19 |
| Chronic Kidney Disease 3 | 1.40 | 0.82 | 2.38 | 0.22 |
| Chronic Kidney Disease 4–5 | 2.74 | 1.46 | 5.14 | 0.002 |
| Thromboembolic Events | ||||
| CHA2DS2-VASc Score | 1.38 | 1.28 | 1.49 | <.0001 |
| Chronic Kidney Disease Stage | 1.09 | 0.87 | 1.36 | 0.45 |
| CHA2DS2-VASc 3–6 | 3.10 | 1.36 | 7.09 | 0.007 |
| CHA2DS2-VASc 7–9 | 9.35 | 3.94 | 22.16 | <.0001 |
| Chronic Kidney Disease 2 | 1.82 | 0.79 | 4.18 | 0.16 |
| Chronic Kidney Disease 3 | 2.23 | 0.97 | 5.14 | 0.06 |
| Chronic Kidney Disease 4–5 | 1.96 | 0.69 | 5.58 | 0.21 |
| Atrial Fibrillation | ||||
| CHA2DS2-VASc Score | 1.15 | 1.08 | 1.22 | <.0001 |
| Chronic Kidney Disease Stage | 1.15 | 0.95 | 1.38 | 0.15 |
| CHA2DS2-VASc 3–6 | 1.56 | 0.98 | 2.49 | 0.06 |
| CHA2DS2-VASc 7–9 | 2.60 | 1.52 | 4.42 | 0.001 |
| Chronic Kidney Disease 2 | 1.62 | 0.88 | 3.02 | 0.12 |
| Chronic Kidney Disease 3 | 1.88 | 1.01 | 3.51 | 0.048 |
| Chronic Kidney Disease 4–5 | 1.92 | 0.82 | 4.47 | 0.13 |
*
Defined by GFR data.