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. Author manuscript; available in PMC: 2018 Sep 12.
Published in final edited form as: Stem Cell Res. 2018 Jul 19;31:83–94. doi: 10.1016/j.scr.2018.07.009

Fig. 2.

Fig. 2.

Dppa4 regulates cell cycle and transcription factor targets in 3T3. A) Overlap of genes downregulated by Dppa4 overexpression in 3T3 and Dppa4 ChIP-Seq peaks in Dppa4 overexpressing 3T3. Hypergeometric distribution was used to calculate probabilities. B) Overlap of genes upregulated by Dppa4 overexpression in 3T3 and Dppa4 ChIP-Seq peaks in Dppa4 overexpressing 3T3. Hypergeometric distribution was used to calculate probabilities. C) Significant gene ontology categories for Dppa4-repressed direct targets. D) Significant gene ontology categories for Dppa4-activated targets. E) qPCR validation of gene expression changes in select Dppa4 targets, n = 4. *p < .05, **p < .01. F) Dppa4 ChIP-qPCR validation of select Dppa4 targets, n = 3. Error bars are the S.E.M.