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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Am J Surg Pathol. 2018 Oct;42(10):1402–1408. doi: 10.1097/PAS.0000000000001121

Figure 2.

Figure 2

Morphological and immunohistochemical features of CHL and AITL with HHV-6 infection. A, CHL, nodular sclerosis type with mononuclear Hodgkin cells and polymorphous background H&E ×400; B, CHL, the Hodgkin cells are highlighted by CD30 stain ×400; C, CHL, There were focal aggregates of cells with intranuclear eosinophilic viral inclusions similar in morphology to the viral lymphadenitis H&E, ×400; D, AITL, there were large atypical cells with intranuclear viral inclusions similar in morphology to the viral lymphadenitis. Arrow points a multinucleate cell with intranuclear inclusion H&E, ×400; E, AITL, there are small mononuclear EBV positive cells, which are clearly distinct from the virally infected cells (arrows), EBER-ISH, ×400. CHL – classic Hodgkin lymphoma, AITL – Angioimmunoblastic T cell lymphoma, EBER-ISH – Epstein Barr Virus early antigen – in situ hybridization.