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Oxygen Consumption Rate (OCR) inhibition (IC50) by metformin, NT1014 and NT1044. All experiments performed in HEK293 cells overexpressing each individual transporter. N.D.=not determined.
| OCR Inhibition, IC50 (micromol/l) | ||||||
|---|---|---|---|---|---|---|
| Compounds | OCT1 | OCT2 | OCT3 | OCTN1 | PMAT | MATE1 |
| Metformin | 240 | 241 | 330 | 4003 | 288 | 5993 |
| NT1014 | 11 | 14 | 49 | 340 | 20 | 365 |
| NT1044 | 10 | 12 | 12 | >5000 | 11 | ND |
