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. Author manuscript; available in PMC: 2019 Sep 15.
Published in final edited form as: Methods. 2018 May 10;148:57–66. doi: 10.1016/j.ymeth.2018.05.004

Table 1.

Comparison of the experimental approaches for investigating target DNA search of proteins.

Methods NMR Single-molecule Biochemical
Capability
Atomic details of DNA scanning +++ a) − −
Direct visualization of protein translocation on DNA − +++ −
Kinetic analysis of protein translocation on DNA ++b) ++ ++
Kinetic analysis of target DNA association + ++ +++
Analysis of target DNA search process in cells + +++ +

Symbols are as follows: +++, well suited; ++, feasible; +, possible, but not well explored; -, not possible.

a)

See Section 4.

b)

See Section 5.