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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Clin Trials. 2018 Aug 3;15(5):499–508. doi: 10.1177/1740774518792259

Figure 5.

Figure 5.

Comparison of the required sample sizes calculated for the HR and for the difference in Restricted Mean Survival Times corresponding to the 35 trials.

Plot A shows a direct comparison of the required sample size under the HR versus that under the difference RMST corresponding to the 35 trials. In Plot B, we compare the required sample size under the HR to the absolute difference (sample size under RMST minus sample size under HR). Plot C compares the required sample size under the HR to the relative difference in required sample sizes ((RMST – HR) / HR).