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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Hear Res. 2018 Mar 11;368:28–40. doi: 10.1016/j.heares.2018.03.002

Figure 4.

Figure 4

Data points show the measured drug concentration remaining in the RW niche in perilymph sampling experiments that used a single 20 μL application to the RW niche in the guinea pig. For dexamethasone-phosphate the measure was the sum of that metabolized to the base form (72%) and that remaining as the phosphate form (28%). Subsequent calculations have assumed an exponential decline of concentration with time as indicated by the curves. For dexamethasone applied as a suspension of micronized solid drug, a uniform concentration over the application period was assumed in calculations.