Figure 1. Representative microscopic photographs and in vivo optical images.

CoNV developed in the ICs of the mice one week after suturing, at which time the annular sectoral neovascularized area was measured (A, G). In the pre-scan, autofluorescence was detected, and the region of interest was determined (white dotted line, B, H). LHT7-Cy5.5 showed a high distribution in the neovascularized IC for 4h after its topical application (C-E), which was reduced at 6h (F). Free-Cy5.5 control showed an even distribution in both the SC and IC regardless of neovascularization (I-L). θ: Central angle in radians; r₁: Radius of the corneal center to the CoNV starting point; r₂: Radius of the corneal center to the CoNV end point.