Fig. 7.

A potential model for how TTK promotes EMT in TNBC cells. In normal breast cells, the TTK expression level is low while that for KLF5 is higher, and, KLF5 induces the transcription of miR-200 family members and represses miR-21 expression, leading to the epithelial phenotype. However, in TNBC cells, higher TTK expression leads to decreased KLF5 expression, resulting in the downregulation of miR-200s and upregulation of miR-21 and the induction of EMT in TNBC cells