Fig. 2.

Cumulative risk of cardiovascular diseases in patients diagnosed during 1987-1999 and aged 50 years or younger at breast cancer diagnosis, by internal mammary chain irradiation and cardiovascular disease risk factors (including smoking) at breast cancer diagnosis. IMC, internal mammary chain; CVD, cardiovascular disease; CHD, ischemic heart disease; VHD, valvular heart disease; HF, heart failure. The analyses of ischemic heart disease, valvular heart disease, and heart failure shown in this figure include all diagnoses of cardiovascular disease, e.g. if a patient was diagnosed with ischemic heart disease and then later with valvular heart disease then both events are counted. Patients with a specific cardiovascular diagnosis before start of time at risk were excluded from analysis with that specific diagnosis as endpoint (n=50 for ischemic heart disease, n=18 for valvular heart disease, and n=36 for heart failure)