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. 2018 Sep 11;8:13642. doi: 10.1038/s41598-018-32067-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Scheme of cascade of events representing the role of zinc in the regulatory crosstalk promoting myogenesis. Zinc ions influx from extracellular medium through membrane Zip transporter mediate phosphorylation of Zip7 endoplasmic reticulum transporter. Activation of Zip7 produces a release of intracellular storage of Zn²⁺ and subsequent phosphorylation of protein kinase Akt and consequently enhances myogenic differentiation. Myotube formation, in turn, stimulate Zn²⁺ extracellular uptake, enhancing myogenic differentiation process and myotubes development. (1) References^28,35. (2) Reference³⁵. (3) References^9,37. (4) References^9,37.