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. 2018 Sep 11;8:13587. doi: 10.1038/s41598-018-31850-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Structure of the trans-translating state of Ms 70S ribosome. (a) Cryo-EM map of the tmRNA-SmpB complex bound 70S ribosome at 12.5 Å resolution. Density is shown as surface. tmRNA is shown in purple, SmpB in green, and A-tRNA in red (left). LSU in transparent blue showing the tmRNA-TLD and SmpB occupying the P-site and tRNA occupying A-site (right). (b) Architecture of tmRNA and SmpB when bound to the 70S. TLD is shown in purple, psuedoknots (PK) 1–4 are in deep green, pink, brown, and yellow, respectively. Helix 2 (H2) is in magenta, helix 5 (H5) in light blue, MLD in grey (stop codon in black), and SmpB in green. (c) Comparison of the structure of a typical tRNA with tmRNA-TLD and SmpB complex showing how tmRNA (TLD) and SmpB complex mimics a tRNA.