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. 2018 Sep 11;8:13607. doi: 10.1038/s41598-018-31945-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Estimations of V23T MscL’s changes in dipole and capacitive energies as a result of transitions to the expanded (subconductive) and open states. Simplified cylindrical representations of three main conformations of V23T MscL (closed, expanded, and open) overlaid on atomistic models of respective states presented as surfaces. Grey regions represent high-dielectric (polar) and pink represent low-dielectric (apolar) segments of the protein; cyan domain in the expanded (subconductive) state shows a polar (likely hydrated) occlusion of the pore; green and yellow represent polar and apolar regions of the annular lipids around the protein. Numbers represent approximate thicknesses and diameters of different dielectric segments that undergo conformational changes in nm. The red and blue lines depict equipotential surfaces around the protein and membrane, in this particular case blue line designates positive voltage in the outer (periplasmic) compartment.