Figure 11.

Effects of Mdivi-1 on mitochondrial dynamics and HMGB1 translocation in CA1 neurons 3 days after SE. Mdivi-1 aggravates mitochondrial elongation and mitochondrial HMGB1 translocation in CA1 neurons following SE. (A) Representative photos of mitochondria (Mito, green) and HMGB1 (red) in CA1 neurons following SE. Bar = 5 μm. (B,C) Quantification of the nuclear HMGB1 intensity (B) and the fraction of HMGB1 positive mitochondria in total mitochondria (C) in CA1 neurons 3 days after SE. Open circles indicate each individual value. Horizontal bars indicate mean value. Error bars indicate SEM (*,^#p < 0.05 vs. control- (Cont) and vehicle-treated animals, respectively; n = 7, respectively).