Figure 12.

Effects of WY14643 on mitochondrial dynamics and HMGB1 translocation in CA1 neurons 3 days after SE. WY14643 mitigates mitochondrial elongation and mitochondrial HMGB1 translocation in CA1 neurons following SE. (A) Representative photos of mitochondria (Mito, green) and HMGB1 (red) in CA1 neurons following SE. Bar = 5 μm. (B,C) Quantification of the nuclear HMGB1 intensity (B) and the fraction of HMGB1 positive mitochondria in total mitochondria (C) in CA1 neurons 3 days after SE. Open circles indicate each individual value. Horizontal bars indicate mean value. Error bars indicate SEM (*,^#p < 0.05 vs. control- (Cont) and vehicle-treated animals, respectively; n = 7, respectively).