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. 2018 Sep 12;7:153. doi: 10.1038/s41426-018-0154-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Groups of ten mice were inoculated with one or two doses, with a 3-week interval, of 10⁶ EID₅₀ of the H7N9/AAca virus vaccine. Three weeks after the last dose, sera were collected to determine HI (a) and NT (b) antibody titers by using the homologous H7N9/AAca virus and the heterologous CK/S1220 and CK/SD008-PB2/627 K viruses, respectively. The dotted lines indicate the lower limit of detection