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. 2018 Sep 5;9:2018. doi: 10.3389/fimmu.2018.02018

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Copyright © 2018 Gungl, Biasin, Wilhelm, Olschewski, Kwapiszewska and Marsh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Blocking of IL-13 signaling decreases inflammation in Fra2 TG mice. Flow cytometric analysis of inflammatory cells in the bronchoalveolar lavage fluid (A,B) and of lung homogenates (C,D) of WT (n = 8) or Fra2 TG mice treated with anti-IL-13 neutralising (n = 6) or isotype (IgG, n = 5) antibodies: (A,C) Heatmap overview of the relative proportion of inflammatory cell populations, Z-scores are shown. (B,D) Changes in the absolute abundance of individual cell populations. AlvMp, alveolar macrophages; PMN, polymorphonuclear neutrophils; EOS, eosinophils; IntMp, interstitial macrophages; DC, dendritic cells. (E) Quantitative real-time PCR analysis of key inflammatory mediators in mouse lung homogenates. (F) IL-13 protein levels measured in lung homogenate (LH), bronchoalveolar lavage fluid (BALF) and plasma of WT and Fra2 TG mice treated with isotype control (IgG) or anti-IL-13 antibodies. ^*p < 0.05, ^**p < 0.01, ^*** p < 0.001.