Table 5.
Previously reported results of oral administration of TXA in total knee arthroplasty.
| Authors | Year | Study design | Dosing regimens | Tourniquet | Drain | No. of patients | Reduced blood loss | Reduction of Hb | Thromboembolic complications | No. of transfusion | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TXA | Control | TXA | Control | TXA | Control | ||||||||
| Zohar et al. | 2004 | RCT | 1 g TXA 60 min before surgery; 1 g TXA every 6 h for 3 times | Yes | Yes | 20 | 20 | Significant | NA | 0 | 0 | 4 | 12 |
| Charoencholvanich et al. | 2011 | RCT | 10 mg/kg before deflation; 0.5 g oral TXA for 5 days | Yes | Yes | 50 | 50 | Significant | Significant | 0 | 0 | 28 | 45 |
| Alipour et al. | 2013 | RCT | 1 g oral TXA before surgery; 1 g oral TXA every 6 h for 18 h postoperatively | Yes | Yes | 26 | 27 | Significant | NA | 0 | 0 | NA | NA |
| Lee et al. | 2017 | RCT | 1 g oral TXA 2 hours before surgery; 1 g oral TXA 6 and 12 h postoperatively | Yes | Yes | 95 | 95 | Significant | Significant | 1 DVT/1 PE | 1 DVT/0 PE | 1 | 3 |
| Yuan et al. | 2017 | RCT | 20 mg/kg oral TXA 2 hours before surgery; 2 g oral TXA 12 h postoperatively | Yes | Yes | 140 | 140 | NA | Significant | 1 DVT/0 PE | 1 DVT/0 PE | 15 | 36 |
NA = not available, RCT = randomized controlled trial, DVT = deep venous thrombosis, and PE = pulmonary embolism.