Table 1.

GCR rates of strains with defects in SWR-C/Htz1 and Mrc1/Tof1/Csm3^a

Relevant genotype	dGCR assay			sGCR assay			uGCR assay
	RDKY	Rateb (x 10−8)	Fold changec	RDKY	Rate (x 10−9)d	Fold change	RDKY	Rate (x 10−9)	Fold change
Wild typee	7635	8.1 [6.4–15]	1.0	7964	6.1 [4.3–18]	1.0	8625	1.8 [0.7–4.1]	1.0
swr1Δ e	7785	16 [11–34]	2.0	9077	8.4 [5.0–15]	1.4	8808	0.8 [0.6–1.1]	0.5
htz1Δ	8969	14 [10–22]	1.7	9079	2.8 [2.2–4.4]	0.5	8810	0.7 [0.4–1.7]	0.4
mrc1Δ e	8301	26 [18–44]	3.2	9081	56 [21–100]	9.1	8804	3.0 [1.4–3.8]	1.7
mrc1Δ swr1Δ e	8302	409 [152–964]	50.3	9083	304 [254–402]	49.5	9085	280 [128–514]	155
mrc1Δ htz1Δ	8975	350 [269–456]	43.1		n.d.	–	9087	215 [102–427]	119
mrc1-aq	8305	18 [12–34]	2.2	9089	7.3 [6.4–8.7]	1.2	9091	14 [9.1–41]	7.6
mrc1-aq swr1Δ	8306	19 [12–43]	2.3	9093	7.0 [4.4–11]	1.1	9095	54 [36–69]	30
mrc1-aq htz1Δ	9097	18 [11–55]	2.2	9099	8.3 [5.2–10]	1.4	9101	62 [4.3–110]	34
mrc1-1-843	8967	22 [15–30]	2.7	9102	24 [18–47]	3.9	8814	2.1 [1.1–4.3]	1.2
mrc1-1-843 swr1Δ	8973	219 [132–341]	27.0	9104	315 [222–444]	51.3	9106	450 [252–623]	250
mrc1-1-843 htz1Δ	9108	219 [175–316]	26.9	9110	148 [103–342]	24.1	9112	76 [51–156]	42
tof1Δ	8963	22 [15–37]	2.7	9114	24 [20–46]	3.9	8816	2.4 [1.5–4.2]	1.3
tof1Δ swr1Δ e	8971	51 [36–116]	6.3	9115	64 [42–139]	10	9117	12 [7.6–22]	6.8
tof1Δ htz1Δ	9119	105 [48–201]	12.9		n.d.	–	9121	7.1 [2.3–8.5]	3.9
csm3Δ	8965	34 [20–76]	4.1	9128	25 [10–52]	4.1	8806	5.0 [2.7–9.3]	2.8
csm3Δ swr1Δ e	8972	72 [50–95]	8.9	9130	54 [41–67]	8.8	9132	7.6 [5.0–12]	4.2
csm3Δ htz1Δ	9134	90 [59–202]	11.0		n.d.	–	9136	3.2 [1.5–5.7]	1.8

^ap values for significance calculated using the Mann-Whitney two-tailed test are presented in Supplementary Data 1.

^bThe numbers in square brackets represent the 95% confidence interval for each rate

^cFold change = fold change with respect to the wild-type rate for each assay

^dn.d. not determined

^eRates for the corresponding dGCR strains generated by systematic crosses and haploid selection⁶ are as follows (x10⁻⁸): wild type 8.6 [4.7–13] (1), mrc1Δ 31 [14–68] (3.6), swr1Δ 13 [6.7–21] (1.5), mrc1Δ swr1Δ 396 [164–514] (46.1), tof1Δ swr1Δ 41 [28–55] (4.8), and csm3Δ swr1Δ 46 [28–194] (5.4); 95% confidence intervals and fold changes with respect to the wild type are indicated in square brackets and parentheses, respectively