Table 3.
Remodeling markers | SAL | OVA | OVA-RHOi | OVA-anti-IL17 | OVA-RHOi-anti-IL17 | |
---|---|---|---|---|---|---|
Airway | MMP-9 (cells/104μm2) | 2.4 ± 0.75 | 7.25 ± 1.79∗ | 3.49 ± 0.82∗∗ | 2.36 ± 0.72∗∗ | 1.37 ± 0.46∗∗ |
Airway | MMP-12 (cells/104μm2) | 0.51 ± 0.35 | 9.78 ± 0.81∗ | 0.51 ± 0.3∗∗ | 2.08 ± 0.84∗∗ | 2.35 ± 0.88∗∗ |
Airway | TIMP-l (cells/104μm2) | 0.21 ± 0.21 | 6.11 ± 1.24∗ | 1.57 ± 0.44∗∗ | 2.94 ± 1.01∗∗ | 1.66 ± 0.72∗∗ |
Airway | TGF-β (cells/104μm2) | 2.52 ± 0.91 | 12.01 ± 2.28∗ | 4.18 ± 1.06∗∗ | 2.84 ± 0.84∗∗ | 0.84 ± 0.41∗∗ |
Airway | Collagen fibers (%) | 5.78 ± 0.73 | 16.48 ± 0.78∗ | 3.72 ± 0.44∗∗ | 3.45 ± 0.66∗∗ | 5.82 ± 0.48∗∗ |
Airway | Decorin (%) | 0.41 ± 0.12 | 5.53 ± 2.53∗ | 0.58 ± 0.19∗∗ | 1.54 ± 0.31∗∗ | 1.55 ± 0.23∗∗ |
Airway | Fibronectin (%) | 0.45 ± 0.08 | 1.0 ± 0.18∗ | 0.21 ± 0.04∗∗, # | 0.98 ± 0.23∗ | 0.28 ± 0.05∗∗, # |
Airway | Biglycan (%) | 0.48 ± 0.09 | 1.32 ± 0.09∗ | 0.22 ± 0.05∗∗ | 0.6 ± 0.11∗∗, & | 0.75 ± 0.09∗∗, & |
∗p < 0.05 compared to SAL group; ∗∗p < 0.05 compared to OVA group; #p < 0.05 compared to OVA-anti-IL17; &p < 0.05 compared to OVA-RHOi.