Table 4.
Remodeling markers | SAL | OVA | OVA-RHOi | OVA-anti-IL17 | OVA-RHOi-anti-IL17 | |
---|---|---|---|---|---|---|
Alveolar septa | MMP-9 (cells/104μm2) | 11.4 ± 1.25 | 19.78 ± 2.01∗ | 13.68 ± 1.08∗∗ | 8.3 ± 0.7∗∗, & | 11.28 ± 0.8∗∗ |
Alveolar septa | MMP-12 (cells/104μm2) | 2.62 ± 0.55 | 7.39 ± 1.08∗ | 4.7 ± 0.71∗∗ | 4.16 ± 0.6∗∗ | 2.83 ± 0.43∗∗ |
Alveolar septa | TIMP-1 (cells/104μm2) | 0.83 ± 0.2 | 8.72 ± 0.85∗ | 5.65 ± 0.61∗, ∗∗ | 4.95 ± 0.61∗, ∗∗ | 4.75 ± 0.72∗, ∗∗ |
Alveolar septa | TGF-β (cells/104μm2) | 3.8 ± 0.7 | 14.59 ± 1.7∗ | 11.16 ± 0.96∗, ∗∗ | 7.95 ± 1.0∗, ∗∗ | 2.62 ± 0.48∗∗, $ |
Alveolar septa | Collagen fibers (%) | 6.89 ± 0.5 | 12.43 ± 0.7∗ | 6.08 ± 0.35∗∗, # | 4.39 ± 0.29∗, ∗∗ | 7.06 ± 0.38∗, ∗∗, # |
Alveolar septa | Decorin (%) | 5.57 ± 0.7 | 13.81 ± 1.05∗ | 5.28 ± 0.57∗∗ | 4.03 ± 0.38∗∗ | 5.06 ± 0.5∗∗ |
Alveolar septa | Fibronectin (%) | 1.38 ± 0.09 | 3.02 ± 1.29∗ | 0.28 ± 0.04∗, ∗∗, # | 1.23 ± 0.26∗∗ | 0.56 ± 0.07∗, ∗∗ |
Alveolar septa | Biglycan (%) | 1.2 ± 0.11 | 3.64 ± 0.29∗ | 0.18 ± 0.05∗, ∗∗ | 1.54 ± 0.15∗∗, & | 3.0 ± 0.26∗, ∗∗, & |
∗p < 0.05 compared to SAL group; ∗∗p < 0.05 compared to OVA group; $p < 0.05 compared to OVA-RHOi and OVA-anti-IL17; #p < 0.05 compared to OVA-anti-IL17; &p < 0.05 compared to OVA-RHOi.