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. 2018 Sep 5;9:1978. doi: 10.3389/fimmu.2018.01978

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Copyright © 2018 Dam, Maier, Hocking, Carlin, Ng and Buckner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-21R levels correlate with IL-21-mediated pSTAT3 signaling. Correlation of IL-21R expression and pSTAT3 fold change in CD20⁺ (A), total memory B cells (B), and naïve B cells (C). pSTAT3 levels were assessed by stimulating with IL-21 for 45 min and measuring pSTAT3 gMFI with no stimulation or with stimulation. Fold change was calculated by dividing IL-21 stimulation pSTAT3 gMFI by the no stimulation pSTAT3 gMFI. As there were no differences in slope between controls and RA patients, the correlation was conducted on both controls (black circles) and RA patients (gray triangles) (n = 116). Correlation was assessed with the Pearson correlation.