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. 2018 Sep 5;9:1978. doi: 10.3389/fimmu.2018.01978

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Copyright © 2018 Dam, Maier, Hocking, Carlin, Ng and Buckner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PRDM1 levels are enhanced in memory B cells following IL-21 stimulation. (A) SOCS1 (left) and SOCS3 (right) mRNA expression in CD20⁺ and total memory B cells from (black circles) Control (n = 7), (gray triangles) RA (n = 14) subjects as assessed by mRNA flow cytometry. (B) miR155 levels in total and memory B cells (black circles) Control (n = 7), (gray triangles) RA (n = 14) subjects collected with miRNA flow cytometry. (C) PRDM1 mRNA levels in memory B cells from control (circles, n = 5) and RA subjects (triangles, n = 10) at baseline (filled) and 48 h (unfilled) after stimulation with IL-21 (50 ng/mL) and measured by mRNA flow cytometry (n = 15). Significance was determined using Mann Whitney U tests.