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. 2018 Sep 5;9:1978. doi: 10.3389/fimmu.2018.01978

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Copyright © 2018 Dam, Maier, Hocking, Carlin, Ng and Buckner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased SP1 expression correlates with increased IL-21R expression in memory B cells in RA subjects (A) SP1 protein levels were assessed by flow cytometry in control (n = 6, black circles), RA low IL-21R expressers (n = 6; open squares) and RA high IL-21R expressers (n = 5; gray triangles) in CD20⁺ and memory B cells (CD20⁺CD38⁻CD24⁺) (left). SP1 protein levels from left were correlated with IL-21R protein expression in total B cells in RA and control subjects (n = 17) (right). (B) Representative histogram of mRNA levels from a no probe negative control, SP1 and positive control probe, RPL13A. (C) (left) SP1 mRNA levels were determined in total memory B cells in controls (n = 7, black circles), RA low IL-21R expressers (n = 7; open squares) and RA high IL-21R expressers (n = 6; gray triangles). (right) SP1 mRNA levels from left were correlated with IL-21R protein expression in memory B cells in RA and control subjects combined (n = 20). Significance was determined using Mann Whitney U tests (to compare RA-IL-21^high to controls and RA-IL-21^low) and correlations were assessed with Pearson correlations.