Table 4.

Univariate and multivariate analysis of prognostic parameters of breast cancer death.

		HR (95% CI)	p-value
Univariate analysis
Tumor size	>20 mm vs. ≤20 mm	2.83 (1.44–5.58)	<0.01
Node status	pN1-3 vs. pN0	5.54 (2.30–13.37)	<0.01
Ki67	≥14% vs. <14%	1.40 (0.71–2.60)	0.31
HER2	pos vs. neg	1.41 (0.55–3.65)	0.48
Tumor grade	III vs. I + II	1.49 (0.80–2.78)	0.21
Age	50–69 yrs. vs. <50 or ≥70 yrs.	1.07 (0.56–2.05)	0.84
Ghrelin intensity	0 vs. 1 + 2 + 3	0.39 (0.18–0.88)	0.01
Obestatin intensity	0 vs. 1 + 2 + 3	0.38 (0.11–1.24)	0.11
Multivariate analysis
Tumor size	>20 mm vs. ≤20 mm	1.78 (0.85–3.72)	0.13
Node status	pN1-3 vs. pN0	4.52 (1.82–11.20)	<0.01
Ghrelin intensity	0 vs. 1 + 2 + 3	0.38 (0.17–0.88)	0.02

Hazard ratio (HR) and 95% confidence intervals (CI) obtained from Cox regression models. HER2, human epidermal growth factor receptor 2.