Table 3.

WT1 and altered p53 in OvCa

A. Altered p53 and WT1 expression differ significantly in OvCa according to subtype (n = 196) (p < 0.0001)
Tumour subtype	n	p53/WT1−	p53alt/WT1−	p53/WT1+	p53alt/WT1+
Type 2	96	10 (10.4%)	5 (5.2%)	20 (20.8%)	61 (63.5%)
Type 1	51	30 (58.8%)	13 (25.5%)	4 (7.8%)	4 (7.8%)
Borderline	49	12(24.5%)	11 (22.4%)	23 (46.9%)	3 (6.1%)
Comparison of stain patterns in type 2 and type 1 tumours
Type 2 ovarian carcinomas			Type 1 ovarian carcinomas

B. Altered p53 and WT1 expression differ significantly in OvCa according to FIGO stage (n = 196) (p < 0.0001)
FIGO stage	n	p53/WT1−	p53alt/WT1−	p53/WT1+	p53alt/WT1+
FIGO IV	19	1 (5.3%)	3 (15.7%)	4 (21.1%)	11 (57.9%)
FIGO III	75	10 (13.3%)	5 (6.7%)	22 (29.3%)	38 (50.7%)
FIGO II	23	6 (26.1%)	6 (26.1%)	3 (13.0%)	8 (34.8%}
FIGO I	79	35(44.3%)	15 (19.0%)	18 (22.8%)	11 (13.9%)
Comparison of stain patterns in FIGO stages III and IV and FIGO stages I and II
FIGO III and IV			FIGO I and II

C. Altered p53 and WT1 expression differ significantly in OvCa according to tumour grade (n = 196) (p < 0.0001)
Tumour grade	n	p53/WT1−	p53alt/WT1−	p53/WT1+	p53alt/WT1+
Grade 3	102	13 (12.8%)	7 (6.9%)	21 (20.6%)	61 (59.8%)
Grade 2	40	24 (60.0%)	11 (27.5%)	2 (5%)	3 (7.5%)
Grade 1	5	3 (60.0%)	0 (0%)	1 (20.0%)	1 (20.0%}
Borderline/LMP	49	12 (24.5%)	11 (22.4%)	23 (46.9%)	3 (6.2%)
Comparison of stain pattern in high grade vs. low grade ovarian carcinomas
Grade 3 ovarian carcinomas			Grade 1 and 2 ovarian carcinomas
D. Altered p53 and WT1 expression differ significantly in OvCa used in survival analyses according to subtype (n = 96) (p < 0.0001)
Tumour subtype	n	p53/WT1−	p53alt/WT1−	p53/WT1+	p53alt/WT1+
Type 2	61	7 (11.5%)	2 (3.3%)	12 (19.7%)	40 (65.6%)
Type 1	35	21 (60%)	11 (31.4%)	3 (8.6%)	0 (0%)
Comparison of stain patterns in type 2 and type 1 tumours used in survival analyses
Type 2 ovarian carcinomas			Type 1 ovarian carcinoma