Fig. 1. BMP pathway gene expression is deregulated in CP-CML and is associated with TKI response.

a The BMP pathway and its downstream genes were analysed in 30 CP-CML CD34⁺ samples (stem/progenitor population) and 30 MNC CP-CML samples from the SPIRIT2 clinical trial using the Fluidigm Biomark system. Four normal CD34⁺ BM samples, two peripheral blood CD34⁺ normal donor samples and four normal MNC samples were used as comparators. Statistical analysis was performed using Welch’s test. b SPIRIT2 sample follow-up in CD34⁺ and MNC samples from ELN optimal, warning and failure patients. Analysis was performed by comparing the expression of each gene in poor, intermediate and good responders to the normal donors. Statistical analysis was performed using Student’s paired t-test. **p < 0.01–0.001, *p < 0.05–0.01