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. 2018 Sep 11;9(9):923. doi: 10.1038/s41419-018-0948-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Representative images of WS (AG03141, AG00780, AG06300) and WT (AG10803) fibroblasts before Sendai virus infection and on Day 5 post-infection. Bar = 100 μm. b Representative images of WRN knockout (WRN-ES1) and WT (H9) human embryonic stem cells-derived MSCs before Sendai virus infection and on Day 5 post-infection. Bar = 100 μm. c The efficiency of iPSC generation from WS and WT fibroblasts. Values represent the mean percentage of alkaline phosphatase (AP)-positive clones among the number of plated cells. **P < 0.001. d The efficiency of iPSC generation from WRN-ES1-, WRN-ES2-, and H9-derived MSCs. Values represent the mean percentage of alkaline phosphatase (AP)-positive clones among the number of plated cells. **P < 0.001. e Telomerase activity of WS and WT groups at reprogramming Day 0, 3, and 6. f Fold change of telomerase activity at different reprogramming time points (Day 3, Day 6) normalized to that of Day 0 in WS and WT groups. WS Werner syndrome, WT Wild-type, WRN-ES WRN knockout human embryonic stem cells, H9 WT human embryonic stem cells