Table 3.
Tumour characteristics of cancers detected by the 1st reader and of cancers additionally detected by the 2nd reader at blinded double reading
| Cancers detected by 1st reader (n = 616) | Cancers additionally detected by 2nd reader (n = 82) | P-value | |
|---|---|---|---|
| Mammographic abnormality | |||
| Mass | 388 (63.0) | 39 (47.6) | 0.113 |
| Microcalcifications | 129 (20.9) | 28 (34.1) | |
| Mass with microcalcifications | 52 (8.4) | 6 (7.3) | |
| Asymmetry | 7 (1.1) | 1 (1.2) | |
| Architectural distortion | 40 (6.5) | 8 (9.8) | |
| Type of cancer | |||
| DCIS | 108 (17.5) | 21 (25.6) | 0.110 |
| Invasive | 508 (82.5) | 61 (74.4) | |
| DCIS grade | |||
| Low | 17 (15.7) | 5 (23.8) | 0.616 |
| Intermediate | 39 (36.1) | 9 (42.9) | |
| High | 52 (48.1) | 7 (33.3) | |
| Histology of invasive cancers | |||
| Ductal | 407 (80.1) | 47 (77.0) | 0.368 |
| Lobular | 54 (10.6) | 4 (6.6) | |
| Mixed ductal/lobular | 15 (3.0) | 4 (6.6) | |
| Other | 32 (6.3) | 6 (9.8) | |
| Tumour size of invasive cancers | |||
| T1 (≤20 mm) | 404 (79.5) | 53 (86.9) | 0.103 |
| T2+(>20 mm) | 104 (20.5) | 8 (13.1) | |
| Lymph node status of invasive cancers | |||
| N+ | 117 (23.0) | 11 (18.0) | 0.324 |
| N- | 383 (75.4) | 48 (78.7) | |
| Unknown | 8 (1.6) | 2 (3.3) | |
| Bloom & Richardson grade | |||
| I | 202 (39.8) | 36 (59.0) | 0.021 |
| II | 236 (46.5) | 16 (26.2) | |
| III | 63 (12.4) | 9 (14.8) | |
| Unknown | 7 (1.4) | 0 | |
| Oestrogen receptor status | |||
| Positive | 460 (90.6 | 56 (91.8) | 0.819 |
| Negative | 45 (8.9) | 5 (8.2) | |
| Unknown | 3 (0.6) | 0 | |
| Progesterone receptor status | |||
| Positive | 369 (72.6) | 39 (63.9) | 0.378 |
| Negative | 136 (26.8) | 22 (36.1) | |
| Unknown | 6 (1.2) | 0 | |
| Her2/Neu receptor status | |||
| Positive | 44 (8.7) | 8 (13.1) | 0.292 |
| Negative | 458 (90.2) | 53 (86.9) | |
| Unknown | 6 (1.2) | 0 | |
| Final surgical treatment | |||
| Breast conserving surgery | 494 (80.2) | 61 (74.4) | 0.534 |
| Mastectomy | 114 (18.5) | 20 (24.4) | |
| No surgery | 8 (1.3) | 1 (1.2 | |
DCIS ductal carcinoma in-situ