Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Sep 11;8:13641. doi: 10.1038/s41598-018-31804-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Effect of an inversion in the eating schedule for different architectures. The circular plot summarises the effect of a shift from nighttime feeding (NF) to daytime feeding (DF) on the phase (arrow direction) and on the amplitude (arrow length) of clock genes and metabolic variables in 3 conditions. (A,B) In the “Physiological” condition (where the local clock entrained by the central pacemaker controls the expression of exocytosis factors, panel A), there is differential phase shift in clock gene expression (compare dotted and solid red arrows) leading to hypoinsulinemia (reflected here by the reduced length of the dotted green arrow). (C,D) In the “No central clock” condition (where the local clock controls the expression of exocytosis factors, panel C), all genes shift by 12 h and the level of insulin is the same during nighttime and daytime feeding (panels D). (E,F) In the “No clock at all” condition (where the expression of exocytosis factors is not under the control of the clock, panel E), the levels of the metabolic variables are the same during nighttime and daytime feeding (panel F).