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. 2018 Sep 11;9:3686. doi: 10.1038/s41467-018-05940-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — IL-37b expression among IL-37bWT and Variants in IL-37b transgenic mice. a The agarose gel confirms the IL-37b insert in IL-37WT, V1 and V1V2 transgenic mice which is absent in the background (control) WT strain. b IL-37b production in the blood cell lysates of tgIL-37WT, tgIL-37V1 and control mice. c Semi-quantitative band density analysis of IL-37b from panel b normalized to β-actin. Data are means ± SD (n = 3/group). ***p < 0.001(unpaired two-tailed Student’s t-test). d IL-37b production in the blood cell lysates of tgIL-37WT and tgIL-37V1V2 mice (n = 3/group). e IL-6 expression level in the supernatant of BMDM (Bone marrow-derived macrophage) from tgIL-37WT and tgIL-37V1 mice at various LPS concentrations. The results are expressed as the mean ± SD. **p < 0.01, ***p < 0.001 (One-way ANOVA and Sidak multiple comparisons test). Results are representative of three independent experiments. f BMDM IL-1β expression by tgIL-37WT and tgIL-37V1 mice at various LPS concentrations in presence of ATP. The results are expressed as the mean ± SD. *p < 0.05, ***p < 0.001 (One-way ANOVA and Sidak multiple comparisons test). (+) indicates the ATP stimulation for BMDM. Results are representative of three independent experiments. g The IL-1β expression level in the gingival tissues of ligature induced periodontitis model between IL-37WT and IL-37V1 transgenic mice group. The results are expressed as the mean ± SD (n ≥ 6/group). *p < 0.05 (unpaired two tailed Student’s t test). h Representative three-dimensional maxillary molars of IL-37WT and V1 transgenic mice in ligature induced periodontitis model. Scale bar is 0.5 mm. i The quantitative data of the distance from CEJ-ABC of first and second molar root in buccal side for each group. The results are expressed as the mean ± SD (n ≥ 5/group). (unpaired two tailed Student’s t test). *p < 0.05