Table 1.
GCF- IL-1β levels among IL-37 variants haplotypes
| Variant 1a Rs3811046 | Variant 2b Rs2723187 | N | Mean GCF IL-1β ng/ml (StErr) |
|---|---|---|---|
| 1.1 (TT) | 1.1 (CC) | 2181 | 134.5 (3.12) |
| 1.1 (TT) | 1.2 (CT) | 0 | — |
| 1.1 (TT) | 2.2 (TT) | 0 | — |
| 1.2 (TG) | 1.1 (CC) | 1304 | 161.0 (4.03)* |
| 1.2 (TG) | 1.2 (CT) | 515 | 163.7 (6.42)* |
| 1.2 (TG) | 2.2 (TT) | 0 | — |
| 2.2 (GG) | 1.1 (CC) | 221 | 186.8 (9.80)*,*** |
| 2.2 (GG) | 1.2 (CT) | 155 | 172.3 (11.70) **,**** |
| 2.2 (GG) | 2.2 (TT) | 32 | 253.7 (25.75) *,*****,#,## |
aIL37 Variant 1, lead SNP rs3811046- 1.1 (TT), 1.2 (TG), 2.2 (GG)
bIL37 Variant 2 lead SNP rs2723187- 1.1 (CC) 1.2 (CT), 2.2 (TT)
Overall p value (GLM) < 0.0001
Pairwise p values compared to 1.1/1.1—*p < 0.0001 **p = 0.0018
Pairwise p values compared to 1.2/1.1 or 1.2/1.2—***p = 0.01, ****p = 0.004, *****p = 0.0004
Pairwise p values compared to 2.2/1.1 #p = 0.015, compared to 2.2/1.2 ##p = 0.004