Table 2.
Association of rs3811046 with chronic and aggressive periodontitis
| Periodontitis diagnosis | N | Odds ratio (95% CI) |
|---|---|---|
| Dental ARIC PPC-A (Health) | n = 1461 | Referent |
| Dental ARIC PPC-B (Mild disease) | n = 811 | 1.10 (0.92–1.32) |
| Dental ARIC PPC-C (High Gingival Index) | n = 158 | 1.20 (0.86–1.68) |
| Dental ARIC PPC-D (Tooth Loss) | n = 530 | 1.10 (0.89–1.35) |
| Dental ARIC PPC-E (Posterior Disease) | n = 827 | 1.01 (0.84–1.21) |
| Dental ARIC PPC-F (Severe tooth Loss) | n = 474 | 1.14 (0.91–1.42) |
| Dental ARIC PPC-G (Severe Disease) | n = 237 | 1.50 (1.12–2.00) |
| German/Dutch -Healthy controls | n = 4210 | Referent |
| German/Dutch -Aggressive Periodontitis | n = 717 | 1.12 (1.01–1.26) |
Adjusted for Examination Center, Gender, Age, Diabetes, Smoking (5-levels) and 10 Ancestry PC’s
Rs3811046 genotype: 1.1 (TT) vs 1.2 (TG + 2.2 GG)
Chronic periodontitis: in the Dental ARIC cohort
Aggressive periodontitis: in the German/Dutch sample